Chemotherapy is a treatment that uses chemical drugs to kill cancer cells. However, chemotherapy drugs can also cause damage to normal cells, leading to a range of side effects. Leg pain can be one of the side effects of chemotherapy. Chemotherapy drugs can cause damage to the bone marrow, which is where blood cells are produced. Low blood cell counts (including white blood cells, red blood cells, and platelets) can cause a range of side effects, including leg pain. Low red blood cell counts can lead to anemia, which can cause leg pain and fatigue. Low white blood cell counts can cause a compromised immune system, making patients more susceptible to infections, which can cause related symptoms, including leg pain. Low platelet counts can cause bleeding, and when there are not enough platelets, patients may experience congestion and bruising, which can cause leg pain. In addition, chemotherapy drugs can cause damage to the nervous system, called neuropathology, which can cause pain and abnormal sensations, including leg pain. This abnormal pain sensation is called chemotherapy-induced peripheral neuropathy. If you are receiving chemotherapy and experience leg pain, it is recommended that you consult your doctor and describe your symptoms in detail so that they can evaluate the condition and take appropriate measures to relieve or treat the leg pain.