Chemotherapy drugs may have some effects on bone mass, but whether chemotherapy causes osteoporosis depends on many factors. Some specific types of chemotherapy drugs, especially steroids such as prednisone and dexamethasone, may increase the risk of osteoporosis. Long-term use of steroids may lead to bone loss and osteopenia, eventually leading to osteoporosis. Other chemotherapy drugs may also have adverse effects on bone mass, but the specific situation needs to be determined according to the patient`s individual physical condition and treatment plan. If you are undergoing chemotherapy or are concerned about the risk of osteoporosis, it is recommended to discuss further with your doctor and seek professional advice and suggestions. The doctor may recommend bone density measurement to assess your bone health and take appropriate preventive measures, such as calcium and vitamin D supplements, and bone health measures (such as moderate exercise and avoiding smoking, excessive drinking, etc.) to reduce the risk of osteoporosis.